Title: Effects of hypertonic sodium chloride hydroxyethyl starch 40 on inflammatory response to uncontrolled hemorrhagic shock in rats
Abstract: Objective To investigate the effect of hypertonic sodium chloride hydroxyethyl starch 40(HHS)on inflammatory response to uncontrolled hemorrhagic shock in rat. Methodes A rat model of uncontrolled hemorrhagic shock was established using the modified Capone method. SD rats (n = 30) were randomly divided into 3 groups, including NC group (normal control group), NS group(normal saline group) and HHS group(hypertonic sodium chloride hydroxyethyl starch 40 group). Heart rate(HR), electrolyte and plasma TNF-α、IL-1β、IL-6 and IL-10 level at various stages of shock and reperfusion were determined and recorded. Results The HR in HHS group and NS group was significantly higher after resuscitation than that after shock (P 0.05). Compared with NS group and NC group, the serum Na+ and Cl- concentration in HHS group increased at 90 min after injury, but restored to normal level at 210 min after injury. Plasma TNF-α、IL-1β and IL-6 level markedly increased after hemorrhagic shock and reperfusion in group NS and group HHS, in addition, plasma TNF-α、IL-1β and IL-6 level were significantly lower in group HHS than those in group NS. Plasma IL-10 level obviously decreased at 210 min after injury in group NS and group HHS, and plasma IL-10 level was significantly higher in group HHS than that in group NS (P 0.05). Conclusion Hypertonic sodium chloride hydroxyethyl starch 40 contributes to the stabilization of hemodynamics and can protect rat against uncontrolled hemorrhagic shock by inhibiting the release of the proinflammatory factors and improving synthesis of anti-inflammatory factors, and restoring the stationarities among cytokine networks.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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