Title: The prospective study on correlation between HBV infection in pregnant women and immune effect of hepatitis B gene vaccine in neonates
Abstract: Objective To explore the effect of maternal HBV infection on neonatal immunization with hepatitis B gene vaccine. Methods Prospective study was used in evaluation of immune effects with ELISA and PCR. Results Hepatitis B virus nucleic acid (HBV DNA) and serologic infectious markers were not found in neonatal series sera. The immunization protective rates in control and infectious group were 93% (28/30) and 83% (39/47), respectively (χ 2=1.74, P 0.05). There were also no statistical significant differences in protective rates among groups or between nationalities (probability, P =0.98; χ 2=0.11, P 0.05). Conclusion The study indicated that anti HBs positive rates in various groups or nationalities increased differently with inoculation times and suggested maternal HBV infectious state at parturition might produce some effects on neonatal anti HBs positive transformation.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
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