Title: Epilepsy: alteration of hippocampal formation
Abstract: Epilepsy is a sort of common and frequently-occurring disease. Mechanisms of it are not well understood. Most of them are temporal lobe epilepsy (TLE). Defining precisely the site of seizure onset has important implications for our understanding of the pathophysiology of temporal lobe epilepsy. A relatively large number of patients for whom seizure control are incomplete. Reevaluation of the extent of the pathology, from animal models, suggests that the seizure focus extends, at least in some cases, beyond the hippocampus. Numerous studies in animal models imply that hippocampal neurogenesis is important for functions such as learning, memory, and mood. Additional studies suggest that hippocampal neurogenesis is very sensitive to physiological and pathological stimuli, such as acute seizures. In this paper was discussed the alteration of hippocampal formation in chronic temporal lobe epilepsy.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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