Title: Effect of arsenic trioxide on apoptosis and VEGF expression of human Hela cells
Abstract: Objective To study the effect of arsenic trioxide (As2O3) on apoptosis and VEGF expression of human HeLa cells. Methods HeLa cells were treated with As2O3 at various concentrations for different time points, and their growth inhibi-tion, apoptosis and VEGF expression were determined by MTT, flow cytometry and Western blotting, respectively. Results As2O3 pretreatment induced the growth inhibition and apoptosis of HeLa cells in a dose-and time-dependent manner (P0.01), and downregulation of VEGF expression. Conclusion As2O3 can in vitro inhibit cell proliferation and VEGF expression of human HeLa cells.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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