Publication Information

{'id': 'https://openalex.org/W2387268941', 'doi': None, 'title': '[In vitro inhibitory effect of dibenzoxanthene CY-B12 on proliferation of tumor cell lines and its possible mechanisms].', 'display_name': '[In vitro inhibitory effect of dibenzoxanthene CY-B12 on proliferation of tumor cell lines and its possible mechanisms].', 'publication_year': 2005, 'publication_date': '2005-12-01', 'ids': {'openalex': 'https://openalex.org/W2387268941', 'mag': '2387268941', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16351789'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16351789', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058845432', 'display_name': 'Xingxiang Pu', 'orcid': 'https://orcid.org/0000-0002-2743-7080'}, 'institutions': [{'id': 'https://openalex.org/I4210098034', 'display_name': 'Key Laboratory of Guangdong Province', 'ror': 'https://ror.org/00swtqp09', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210098034']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xing-Xiang Pu', 'raw_affiliation_strings': ['Skate Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P. R. China.'], 'affiliations': [{'raw_affiliation_string': 'Skate Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P. R. China.', 'institution_ids': ['https://openalex.org/I4210098034']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110426381', 'display_name': 'Jiang Gaofeng', 'orcid': 'https://orcid.org/0009-0006-2957-0551'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gao-Feng Jiang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101420436', 'display_name': 'Yong Chen', 'orcid': 'https://orcid.org/0000-0001-8835-8362'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yong Chen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070727015', 'display_name': 'Zun‐Le Xu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Zun-Le Xu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111757334', 'display_name': 'Li-Jian Xian', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Li-Jian Xian', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '24', 'issue': '12', 'first_page': '1442', 'last_page': '7'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.6559, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.6559, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.6396, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.48710132}, {'id': 'https://openalex.org/keywords/cyclin-b1', 'display_name': 'Cyclin B1', 'score': 0.44270098}], 'concepts': [{'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.70014656}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.6232956}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.58984786}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.5869032}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.5470647}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.52620417}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.48710132}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4690989}, {'id': 'https://openalex.org/C2778437423', 'wikidata': 'https://www.wikidata.org/wiki/Q5198265', 'display_name': 'Cyclin B1', 'level': 5, 'score': 0.44270098}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.43606967}, {'id': 'https://openalex.org/C120504264', 'wikidata': 'https://www.wikidata.org/wiki/Q1147372', 'display_name': 'Cyclin-dependent kinase 1', 'level': 4, 'score': 0.38701117}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38180104}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17786512}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014966', 'descriptor_name': 'Xanthenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020687', 'descriptor_name': 'cdc25 Phosphatases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019926', 'descriptor_name': 'Cyclin B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019926', 'descriptor_name': 'Cyclin B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056744', 'descriptor_name': 'Cyclin B1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014966', 'descriptor_name': 'Xanthenes', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D014966', 'descriptor_name': 'Xanthenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020687', 'descriptor_name': 'cdc25 Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16351789', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.77, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3150875363', 'https://openalex.org/W3141535890', 'https://openalex.org/W3029662562', 'https://openalex.org/W2981352331', 'https://openalex.org/W2883059800', 'https://openalex.org/W2462394877', 'https://openalex.org/W2419125918', 'https://openalex.org/W2418071846', 'https://openalex.org/W2404195220', 'https://openalex.org/W2399884457', 'https://openalex.org/W2388022965', 'https://openalex.org/W2386895431', 'https://openalex.org/W2370349333', 'https://openalex.org/W2368916951', 'https://openalex.org/W2359591957', 'https://openalex.org/W2354206952', 'https://openalex.org/W2351031987', 'https://openalex.org/W2151677017', 'https://openalex.org/W2139831384', 'https://openalex.org/W2052432265'], 'abstract_inverted_index': {'CY-B12,': [0, 133, 180], 'a': [1, 166, 196], 'new': [2], 'dibenzon-xanthene,': [3], 'has': [4, 199], 'been': [5], 'synthesized': [6], 'recently.': [7], 'This': [8], 'study': [9], 'was': [10, 74, 100, 161], 'to': [11], 'investigate': [12], 'the': [13, 110, 119], 'in': [14, 150, 158, 165, 192, 195, 201], 'vitro': [15, 202], 'antiproliferative': [16, 203], 'activity': [17], 'of': [18, 26, 30, 71, 84, 112, 132, 156, 179, 186], 'CY-B12': [19, 27, 164, 188], 'and': [20, 47, 61, 90, 116, 126, 145, 172, 181, 217, 222], 'its': [21], 'possible': [22], 'mechanisms.The': [23], 'inhibitory': [24], 'effects': [25], 'on': [28], 'proliferation': [29, 111], 'gastric': [31], 'carcinoma': [32, 37, 43], 'cell': [33, 38, 44, 50, 85, 104, 213, 219], 'line': [34, 39, 45, 51], 'MGC803,': [35, 113], 'nasopharyngeal': [36], 'CNE-2,': [40, 114], 'oral': [41], 'epithelial': [42], 'KB-3-1,': [46, 115], 'lung': [48], 'cancer': [49], 'Glc82': [52, 117], 'were': [53, 63, 93, 122, 136, 148, 174], 'assessed': [54], 'by': [55, 65, 95, 102, 163, 176, 183], 'MTT': [56], 'assay.': [57], 'Cell': [58], 'cycle': [59, 220], 'distribution': [60], 'apoptosis': [62], 'detected': [64, 101], 'flow': [66], 'cytometry': [67], '(FCM).': [68], 'Apoptotic': [69], 'morphology': [70], 'CNE-2': [72, 134, 151, 159, 193], 'cells': [73, 135, 160, 194], 'observed': [75, 149], 'under': [76], 'fluorescent': [77], 'microscope': [78], 'after': [79], 'Hoechst33258': [80], 'staining.': [81], 'The': [82, 153], 'expression': [83, 155], 'cycle-related': [86, 214], 'proteins': [87], 'Cdc25C,': [88, 216], 'Cdc2,': [89], 'Cyclin': [91, 170], 'B1': [92, 171], 'measured': [94], 'Western': [96], 'blot.': [97], 'DNA': [98, 190], 'damage': [99, 191], 'single': [103], 'gel': [105], 'electrophoresis': [106], '(SCGE).CY-B12': [107], 'obviously': [108], 'inhibited': [109], 'cells;': [118], 'IC(50)': [120], 'values': [121], '7.51,': [123], '9.58,': [124], '8.84,': [125], '15.99': [127], 'micromol/L,': [128], 'respectively.': [129], 'After': [130], 'treatment': [131], 'arrested': [137], 'at': [138], 'G(2)/M': [139], 'phase;': [140], 'chromatin': [141], 'condensation,': [142], 'apoptotic': [143], 'bodies,': [144], 'sub-G1': [146], 'peak': [147], 'cells.': [152], 'protein': [154, 215], 'Cdc25C': [157], 'down-regulated': [162, 182], 'dose-dependent': [167, 197], 'mannerû': [168], 'whereas': [169], 'Cdc2': [173], 'up-regulated': [175], 'low': [177], 'dose': [178, 185], 'high': [184], 'CY-B12.': [187], 'induced': [189], 'manner.CY-B12': [198], 'potent': [200], 'activity,': [204], 'which': [205], 'may': [206], 'be': [207], 'exerted': [208], 'through': [209], 'breaking': [210], 'DNA,': [211], 'down-regulating': [212], 'inducing': [218], 'arrest': [221], 'apoptosis.': [223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2387268941', 'counts_by_year': [], 'updated_date': '2025-01-18T01:58:02.024550', 'created_date': '2016-06-24'}