Title: THE RELATIONSHIP OF IMMUNOPHENOTYPE AND CLINICAL SIGNIFICANCE IN ACUTE LEUKEMIA AND MALIGNANT LYMPHOMA
Abstract: Objective To study the relationship of immune phenotype and prognosis in children with acute leukemia (AL) and malignant lymphoma (ML). Methods An individual nuclear cell was separated from marrow liquid, peripheral blood and tumor tissue and treated with monoclone antibody (McAb). A typing was done by indirect immunofluorescence. The data was analyzed by χ 2 test. Results In 241 cases of AL, there were 147 cases of acute B cell leukemia (B ALL), 14 acute T cell leukemia (T ALL), 11 acute hybrid leukemia (HAL) and 69 myeloid leukemia (AML). There were 9 cases with non Hodgkins lymphoma (NHL) in 11 ML, in which, types BⅢ(3 cases),BⅣ(1), BⅥ(1), TⅡ(2), TⅢ(1) and non T or B(1) were found. The 2 cases with HD were the A + B + type (BⅣ/TⅡ and BⅤ/TⅡ). The positive expression of HLA DR was disadvantageous factor of chemotherapy for AML. The positive CD 34 indicated favorable prognosis for ALL, but it indicated poor prognosis for AML in children. The immune phenotype of ML was consistent with malignant degree pathologically. Conclusion There is a close relationship between immune phenotype of AL and ML and prognosis.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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