Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2387025069', 'doi': 'https://doi.org/10.1182/blood.v79.9.2356.2356', 'title': 'Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes', 'display_name': 'Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes', 'publication_year': 1992, 'publication_date': '1992-05-01', 'ids': {'openalex': 'https://openalex.org/W2387025069', 'doi': 'https://doi.org/10.1182/blood.v79.9.2356.2356', 'mag': '2387025069', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1533322'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood.v79.9.2356.2356', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/79/9/2356/607902/2356.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://ashpublications.org/blood/article-pdf/79/9/2356/607902/2356.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5006015812', 'display_name': 'EV Granowitz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}, {'id': 'https://openalex.org/I4210102414', 'display_name': 'Medical Center Hospital', 'ror': 'https://ror.org/01e2a5576', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210102414']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'EV Granowitz', 'raw_affiliation_strings': ['Department of Medicine, New England Medical Center Hospitals, Boston, MA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, New England Medical Center Hospitals, Boston, MA.', 'institution_ids': ['https://openalex.org/I1290900354', 'https://openalex.org/I4210102414']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035050464', 'display_name': 'BD Clark', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}, {'id': 'https://openalex.org/I4210102414', 'display_name': 'Medical Center Hospital', 'ror': 'https://ror.org/01e2a5576', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210102414']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'BD Clark', 'raw_affiliation_strings': ['Department of Medicine, New England Medical Center Hospitals, Boston, MA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, New England Medical Center Hospitals, Boston, MA.', 'institution_ids': ['https://openalex.org/I1290900354', 'https://openalex.org/I4210102414']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070134622', 'display_name': 'Edouard Vannier', 'orcid': 'https://orcid.org/0000-0001-6654-9053'}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}, {'id': 'https://openalex.org/I4210102414', 'display_name': 'Medical Center Hospital', 'ror': 'https://ror.org/01e2a5576', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210102414']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E Vannier', 'raw_affiliation_strings': ['Department of Medicine, New England Medical Center Hospitals, Boston, MA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, New England Medical Center Hospitals, Boston, MA.', 'institution_ids': ['https://openalex.org/I1290900354', 'https://openalex.org/I4210102414']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110356189', 'display_name': 'MV Callahan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}, {'id': 'https://openalex.org/I4210102414', 'display_name': 'Medical Center Hospital', 'ror': 'https://ror.org/01e2a5576', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210102414']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'MV Callahan', 'raw_affiliation_strings': ['Department of Medicine, New England Medical Center Hospitals, Boston, MA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, New England Medical Center Hospitals, Boston, MA.', 'institution_ids': ['https://openalex.org/I1290900354', 'https://openalex.org/I4210102414']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109310003', 'display_name': 'CA Dinarello', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}, {'id': 'https://openalex.org/I4210102414', 'display_name': 'Medical Center Hospital', 'ror': 'https://ror.org/01e2a5576', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210102414']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'CA Dinarello', 'raw_affiliation_strings': ['Department of Medicine, New England Medical Center Hospitals, Boston, MA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, New England Medical Center Hospitals, Boston, MA.', 'institution_ids': ['https://openalex.org/I1290900354', 'https://openalex.org/I4210102414']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5000, 'currency': 'USD', 'value_usd': 5000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.428, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 155, 'citation_normalized_percentile': {'value': 0.94734, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '79', 'issue': '9', 'first_page': '2356', 'last_page': '2363'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/interleukin-1-receptor', 'display_name': 'Interleukin-1 receptor', 'score': 0.51557606}, {'id': 'https://openalex.org/keywords/beta', 'display_name': 'BETA (programming language)', 'score': 0.44916895}, {'id': 'https://openalex.org/keywords/alpha', 'display_name': 'Alpha (finance)', 'score': 0.44800362}], 'concepts': [{'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.7331532}, {'id': 'https://openalex.org/C2778122271', 'wikidata': 'https://www.wikidata.org/wiki/Q410943', 'display_name': 'Receptor antagonist', 'level': 4, 'score': 0.6590514}, {'id': 'https://openalex.org/C149892131', 'wikidata': 'https://www.wikidata.org/wiki/Q14914156', 'display_name': 'Interleukin 1 receptor antagonist', 'level': 5, 'score': 0.6376581}, {'id': 'https://openalex.org/C137061746', 'wikidata': 'https://www.wikidata.org/wiki/Q736033', 'display_name': 'Peripheral blood mononuclear cell', 'level': 3, 'score': 0.60256916}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.58754843}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.55923456}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5415301}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.5310985}, {'id': 'https://openalex.org/C2777977768', 'wikidata': 'https://www.wikidata.org/wiki/Q15996698', 'display_name': 'Interleukin-1 receptor', 'level': 4, 'score': 0.51557606}, {'id': 'https://openalex.org/C2776174256', 'wikidata': 'https://www.wikidata.org/wiki/Q830842', 'display_name': 'BETA (programming language)', 'level': 2, 'score': 0.44916895}, {'id': 'https://openalex.org/C64943373', 'wikidata': 'https://www.wikidata.org/wiki/Q2651003', 'display_name': 'Alpha (finance)', 'level': 4, 'score': 0.44800362}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.43172902}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.42104286}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3509958}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3283071}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.3260166}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3026833}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.20264328}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1827546}, {'id': 'https://openalex.org/C49453240', 'wikidata': 'https://www.wikidata.org/wiki/Q1592163', 'display_name': 'Construct validity', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C159110408', 'wikidata': 'https://www.wikidata.org/wiki/Q121176', 'display_name': 'Nursing', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2775944032', 'wikidata': 'https://www.wikidata.org/wiki/Q22907659', 'display_name': 'Patient satisfaction', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood.v79.9.2356.2356', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/79/9/2356/607902/2356.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood.v79.9.2356.2356', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/79/9/2356/607902/2356.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.47, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1444196433', 'https://openalex.org/W1496201232', 'https://openalex.org/W1498968793', 'https://openalex.org/W1501266707', 'https://openalex.org/W1518327066', 'https://openalex.org/W1520223434', 'https://openalex.org/W1523484838', 'https://openalex.org/W1532410262', 'https://openalex.org/W1563440540', 'https://openalex.org/W1564545106', 'https://openalex.org/W1566331874', 'https://openalex.org/W1571401829', 'https://openalex.org/W1574330564', 'https://openalex.org/W1588071143', 'https://openalex.org/W1640867939', 'https://openalex.org/W1948682743', 'https://openalex.org/W1989459539', 'https://openalex.org/W1997462850', 'https://openalex.org/W1999701898', 'https://openalex.org/W2001896356', 'https://openalex.org/W2007210793', 'https://openalex.org/W2031782743', 'https://openalex.org/W2041005913', 'https://openalex.org/W204546040', 'https://openalex.org/W2046893011', 'https://openalex.org/W2073598149', 'https://openalex.org/W2074393911', 'https://openalex.org/W2105721964', 'https://openalex.org/W2114576105', 'https://openalex.org/W2117257649', 'https://openalex.org/W2135745523', 'https://openalex.org/W2141048728', 'https://openalex.org/W2183101052', 'https://openalex.org/W2405969444', 'https://openalex.org/W2408955877', 'https://openalex.org/W326172054', 'https://openalex.org/W4231459852', 'https://openalex.org/W4232067394', 'https://openalex.org/W4243467058', 'https://openalex.org/W60358571', 'https://openalex.org/W614601075'], 'related_works': ['https://openalex.org/W4232487818', 'https://openalex.org/W2761748352', 'https://openalex.org/W2387025069', 'https://openalex.org/W2331113734', 'https://openalex.org/W2156016155', 'https://openalex.org/W2149349927', 'https://openalex.org/W2104942849', 'https://openalex.org/W2009750871', 'https://openalex.org/W1992286694', 'https://openalex.org/W1549764586'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2387025069', 'counts_by_year': [{'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-16T11:39:33.831846', 'created_date': '2016-06-24'}