Title: Changes of Serum IL-2 and IL-6 Levels in Patients with Graves′Ophthalmopathy before and after Treated with Iodine-131
Abstract: Objective:To study the changes of serum cytokine levels in patients with Graves'ophthalmopathy (GO) before and after treated with iodine-131.Methods:Using the method radoimmunoassay,the serum levels of interleukin-2 (IL-2) and interleukin-6 (IL-6)of Graves'ophthalmopathy 120 patients before and after treated with iodine-131 and 30 control subjects were measured. Results:In GO patients of pre-treatment,the IL-2 levels were significantly lower,while IL-6 levels were significantly higher than those in the control group (P0.01);After iodine-131 treatment,GO improvement in patients with elevated IL-2 levels,IL-6 levels decreased,while in GO non-changes patients,the IL-2 and the IL-6 levels didn't change obviously(P0.05),GO aggravates the patient IL-2 level goes forward one step compared to before the treatment to reduce,The IL-6 level further elevates. Conclusions:Successful iodine-131 therapy would effectively suppress the to-immune status in Graves'ophthalmopathy patients.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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