Title: MRI diagnosis of pituitary lesions in childhood and adolescence
Abstract: Objective To observe the clinical and MRI features of various pituitary lesions in childhood and adolescence. Methods The MRI findings and clinical features of 31 cases, which had 49 different kinds of pituitary lesions were retrospectively reviewed (21 cases had single lesion, 10 cases had multiple lesions). Results The main causes of pituitary growth hormone deficiency (PGHG) were macroadenomas and hypoplasia of pituitary. Four cases of pituitary hypoplasia were combined with agenesis of stalks, as well as ectopic posterior lobe. In all 13 cases of central diabetes insipidus (CDI), the high signal of posterior lobe did not appear in T1W sagittal images. Eight in 13 of CDI had abnormality of pituitary stalk (2 had thin and 6 had thick stalk). There were 3 cases of Langhan's histocytosis (LCH) and 3 cases of stalk metastases. All of them showed a thickened pituitary stalk, but LCH cases demonstrated additional destruction of flat bones (n=3). In the cases with stalk metastases, brain metastatic lesions could be detected besides stalk lesions (n=3). There were no signs of invasive growth on MRI and after resection in all cases with adenomas. All 5 microadenomas were PRL secreting ones. Three in 7 cases of pituitary macroadenomas had apoplexy. The hyperplasia pituitary had similar imaging features as pituiary adenomas which showed no signs of apoplexy, but their clinical appearance were quite different. Conclusion MRI can show different kinds of pitiuitay lesions clearly, combined with clincal manifestations can make correct diagnosis of pituitary lesions in childhood and adolescence.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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