Title: Protective Effect of L-tetrahydropalmatine on Renal Ischemia Reperfusion Injury in Rats
Abstract: Objective To investigate the effect and protective effect of L-tetrahydropalmatine(L-THP)on renal ischemia-reperfusion injury in rat.Methods Rat models of renal ischemia-reperfusion were established,and 34 male rats were randomly divided into 3 groups,treatment group with L-THP(n=10),renal ischemia-reperfusion injury model group(n=16) and sham operation group(n=8) as the control.L-THP(60 mg/kg) was given intravenously during clamping renal artery in treatment group and one half of the dose was infused after opening the clamp during reperfusion.In modelgroup equal amount of 0.9% sodium chloride solution was given.In the sham operation group(control group),the rats were anesthetized with laparotomy but without blocking renal blood flow.The P-selectin and ICAM-1 expression,malonyldialdehyde(MDA) contents and super oxide dismutase(SOD) activities in renal tissues,level of serum blood urea nitrogen(BUN) and creatinine(Cr) were detected.Results After renal ischemia reperfusion injury,there were significantly up-regulated expressions of Pselectin and ICAM-1,with increased MDA content and declined SOD activity inrenal tissue,and significant increase in BUN and Cr content in model group,and in treatment group with L-THP these effects were significantly depressed as compared with model group.Conclusion It is thought that the adhesion molecules P-selectin and ICAM-1 take part in the process of renal ischemia-reperfusion injury,and L-THP significantly reduce the reaction of lipid peroxidation with a protective effect on renal ischemia-reperfusion injury
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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