Title: Application of dexmedetomidine on senile patients undergoing transurethral resection of prostate
Abstract: Objective To observe the safety of dexmedetomidine and whether it could reduce the side effects on senile patients undergoing transurethral resection of prostate(TURP). Methods Forty senile patients,ASA Ⅰ or Ⅱ, undergoing TURP were randomly divided into two groups:control group (C group)and dexmedetemidine group(D group),with 20 persons each.All persons received subarachnoid block anesthesia. 10 minutes after spinal anesthesia,dexmedetomidine 0.5 μg/kg was given to D group as a bolus dosage in 10 minutes,followed by continuous infusion at a dose of 0.2 μg/(kg·h). The same dose of physiological saline was given to C group. Heart rate(HR), mean arterial pressure(MAP),respiratory(RR),oxygen saturation (SPO2) and the scores of alertness/sedation(OAA/S) scale were recorded at the time points of preanesthesia(T0), 10 minutes after spinal anesthesia(T1), 10 minutes after Dex or saline infusion (T2), the beginning of surgery(T3), 30 minutes after operation (T4) and the end of surgery(T5). Also the side effects of patients in two groups were recorded and the degree of comfort was evaluated. Results In D group, compared with the baseline, MAP decreased at T3-T5, HR decreased at T2-T5, RR decreased at T2-T4,and OAA/S decreased at T2-T5. In C group, compared with the baseline, RR decreased at T4-T5 (P0.05). Compared with C group, in D group, MAP decreased at T3-T5,HR decreased at T2-T5, RR decreased at T3,and OAA/S decreased at T2-T5. The incidence of shivering significantly also reduced while the score of comfort level increased in D group (P0.05). Conclusions Dexmedetomidine is not only safe and effective for the patients undergoing TURP, but also can decrease the incidence of side effects and improve the comfort level.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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