Title: Peginterferon α-2a and adefovir dipivoxil combination therapy for chronic hepatitis B: a Meta-analysis
Abstract: Chronic hepatitis B is caused by hepatitis B virus(HBV).Antiviral therapy is the key point of delaying the development of the disease.Naive monotherapy with either interferon(IFN)or nucleotide analogue(NUC)failed to achieve sustained remission because of the poor response,YMDD mutation and drug resistance after long-term use.Recently,the notion of combination therapy of IFN and NUC during naive-treatment or on-treatment has been proposed.The clinical trial shows no different short-term efficacy between the combination therapy of peg-IFN α-2a with lamivudine and the monotherapy of peg-IFN α-2a alone.The combination of Peg-IFN α-2a with telbivudine possibly resulted in peripheral neuropathy.It is necessary to choose different drugs for combination therapy in different stages of treatment.Based on the clinical trials of the combination therapy of peg-IFN α-2a and adefovir dipivoxil(ADV),controversial results of the efficacy and safety are showed.We performed the meta-analysis to evaluate the efficacy and safety of large sample.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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