Title: Single nucleotide polymorphism and complex diseases
Abstract: Single nucleotide polymorphisms (SNPs) are genomic DNA variations based on single nucleotide transition and transversion, which have a frequency of at least 1%. SNPs are highly abundant, stable, and distributed throughout the genome;they frequently exist as biallelic marker and can be used conveniently for large scale and high throughout analysis. Therefore, SNPs are referred to as the third generation genetic markers which have a bright future in many areas. Most complex diseases, such as diabetes, cancer, heart disease and asthma, are affected by many genes and environmental factors. SNPs can be used in pharmacogenetic studies and in identifying the susceptible genes of complex diseases by linkage disequilibrium and associated analysis.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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