Title: Effect of Edaravone Combined with Low Molecular Weight Heparin Calcium and Aspirin Enteric- Coated Tablets on Acute Progressive Cerebral Infarction
Abstract: Objective To observe the effect of edaravone combined with low molecular weight heparin calcium and aspirin enteric- coated tablets on acute progressive cerebral infarction. Methods 150 patients with acute progressive cerebral infarction admitted to our hospital from September 2009 to December 2012 were randomly divided into treatment group,anticoagulant group and control group,each of 50 cases. Control group was given aspirin enteric- coated tablets and basic treatment,anticoagulant group was given low molecular weight heparin calcium on basis of control group,treatment group was given edaravone and low molecular weight heparin calcium on basis of control group,all treated for 14 days as 1 course. The degree of clinical neurological impairment and efficacy among 3 groups were assessed before and 14 days after treatment. Results 14 days after treatment,the neural function defect score in treatment group were lower than that of other two groups,anticoagulant group was lower than that of control group( P 0. 05). The total efficacy of groups control,anticoagulation and treatment were 76%( 38 / 50),82%( 41 /50) and 90%( 45 /50),respectively. The total efficacy of treatment group was higher than that of other two groups,anticoagulation group was higher than that of control group( P 0. 05); there was no significant adverse reactions in 3 groups. Conclusion Edaravone combined with low molecular weight heparin calcium and aspirin enteric- coated tablets in treating acute progressive cerebral infarction can improve the degree of neural function defect,being obviously effective and safety.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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