Title: STUDIES ON THE CONSTITUENTS OF HUA-ZHONG-WU-WEI-ZI (SCHISANDRA SPHENANTHERA REHD ET WILS)I. THE ISOLATION AND STRUCTURE OF SCHISANTHERIN A.
Abstract:A new lignan, named schisantherin A, has been isolated from the fruits of Hua-Zhong-Wu-Wei-Zi(Schisandra sphenanthera Rehd et Wils)(Magnoliaceae). According to the pharmacological and preliminary clin...A new lignan, named schisantherin A, has been isolated from the fruits of Hua-Zhong-Wu-Wei-Zi(Schisandra sphenanthera Rehd et Wils)(Magnoliaceae). According to the pharmacological and preliminary clinical findings, the schisantherin A is one of the antihepatotoxic principle of this plant. It is a lignan unknown so far. The molecular formula of schisantherin A is found to be C_(30)H_(32)O_9 by mass spectroscopic and elementary analyses. When treated with 10% potassium hydroxide in methanol, it was converted into the corresponding hydroxy compound, schisantherinol A (C_(23)H_(28)O_8) and benzoic acid in high yields. By taking advantage of UV、IR、NMR and mass spectroscopy, the structures of the two compounds, schisantherin A and schisantherinol A, are shown to be Ⅰ_a and Ⅰ_b respectively.Finally, the structure including the positions of all of the functional groups and conformation of schisantherin A is established by double resonance experiments and measurements of intramcolecular nuclear Overhauser effects (NOE). The results are shown in Ⅱ.Read More
Publication Year: 1975
Publication Date: 1975-01-01
Language: en
Type: article
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Cited By Count: 5
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