Title: Studies on the Antidepressant-Like Effect and 5-HT Mechanisms of Flavonoids Extracted from Apocynum venetum Leaves
Abstract: In this study,the classical animal models of depression including the force swimming of the mice was applied to evaluate the antidepressant-like effect of AV-extract.To further search for the neurotransmitter mechanism of antidepression of AV-extract,additionally,the monoaminergic mechanisms involved in the antidepressant-like effect of AV-extract in mice were also assessed.The result showed that AV-extract showed a clear antidepressant-like effect in variety of animal models of depression.The anti-immobility effect of AV-extract(50mg/kg,p.o.)was completely prevented by the pretreatment of mice with ketanserin(5mg/kg,i.g.,a serotonin 5-HT2Areceptor antagonist),cyproheptadine(3mg/kg,i.g.,a serotonin 5-HT2 receptor antagonist).On the other hand,the pretreatment of mice with Way 100635(0.1mg/kg,s.c.,a serotonin 5-HT1A receptor antagonist),did not block the antidepressant-like effect of AV-extract in the TST.Taken together,the data demonstrated that AV-extract produced an antidepressant-like that seems to be dependent on its interaction with the serotonergic(5-HT2Aand 5-HT2 receptors)systems.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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