Title: Effects of electroacupuncture on learning and memory ability and expression of glutamate(Glu) and N-methyl-D-aspartate receptor(NMDAR) in hippocampal of vascular dementia rats
Abstract: Objective To observe the effect of electroacupuncture(EA) on spatial learning and memory ability,hippocampal glutamate(Glu) and N-methyl-D-aspartate receptor(NMDAR) expression in rats with vascular dementia(VD),and explore its underlying mechanism in improving VD.Methods SD rats were randomly divided into control,sham-operation,model,EA groups.Rat model of VD was established by repeated ischemia/reperfusion and pretreated with sodium nitroprusside.EA was applied to Baihui(GV20),Dazhui(DU14) in EA group for 20 min,once daily for 10 days.Morris water maze test was performed to detect the rats' learning-memory ability.Glu and NMDAR produced in hippocampal tissue were examined with immunohistochemical assay.Results In comparison with model group,escape latency(EL) was shortened and target-platform crossing times was increased both significantly in EA group(P0.01).Glu and NMDAR positive cells were remarkably increased in EA-treated rats(P0.01).Conclusions EA can raise expressions of Glu and NMDAR and improve the learning-memory ability in VD rats.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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