Title: Clinical study of Kangai Injection combined with radiotherapy in treatment of advanced esophageal carcinoma
Abstract: Objective To investigate the clinical efficacy of Kangai Injection combined with radiotherapy for advanced esophageal cancer and its effect on immune function and quality of life. Methods Patients with advanced esophageal cancer were randomly divided into control(39 cases) and treatment(39 cases) groups. Patients in the control group were given radiation therapy, and patients in the treatment group were iv administered with 60 mL Kangai Injection, adding 250 mL normal saline for iv drip, once daily, 4 weeks as one course. Two groups were continuous treated for two courses. After treatment, the treatment efficacy, quality of life, and cellular immunity function were evaluated. Results After treatment, the effective rates in the treatment and control groups were 61.54% and 56.41%, respectively, with significant difference between the two groups(P 0.05). The increasing rate of QOL in the treatment and control groups were 74.36% and 43.59%, while body weight improvement rates were 54.61% and 33.33%, and the difference was statistically significant between the two groups(P 0.05). After treatment, CD3+, CD4+, CD4+/CD8+, and NK of the treatment group increased, CD8+ decreased, with statistically significant difference before and after treatment(P 0.01). Those detection indexes were compared with control group, and difference was statistically significant(P 0.01). The indexes of control group were not changed, compared with those before the treatment, the differences had no statistically significance. Conclusion Kangai Injection can improve the quality of life and body weight and reduce toxicity, with good clinical application value for the treatment of advanced esophageal cancer.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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