Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2385009615', 'doi': 'https://doi.org/10.1002/cncr.30037', 'title': 'Phase 2 study of intensified chemotherapy and allogeneic hematopoietic stem cell transplantation for older patients with acute lymphoblastic leukemia', 'display_name': 'Phase 2 study of intensified chemotherapy and allogeneic hematopoietic stem cell transplantation for older patients with acute lymphoblastic leukemia', 'publication_year': 2016, 'publication_date': '2016-05-12', 'ids': {'openalex': 'https://openalex.org/W2385009615', 'doi': 'https://doi.org/10.1002/cncr.30037', 'mag': '2385009615', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27171984'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/cncr.30037', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.30037', 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.30037', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010057352', 'display_name': 'Amir T. Fathi', 'orcid': 'https://orcid.org/0000-0003-4907-6447'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I4210119046', 'display_name': 'Zero to Three', 'ror': 'https://ror.org/01qvk6016', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210119046']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amir T. Fathi', 'raw_affiliation_strings': ['Massachusetts General Hospital Cancer Center, Boston, Massachusetts', 'The first 2 authors contributed equally to this article.'], 'affiliations': [{'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210087915']}, {'raw_affiliation_string': 'The first 2 authors contributed equally to this article.', 'institution_ids': ['https://openalex.org/I4210119046']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082924494', 'display_name': 'Daniel J. DeAngelo', 'orcid': 'https://orcid.org/0000-0001-7865-2306'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I4210119046', 'display_name': 'Zero to Three', 'ror': 'https://ror.org/01qvk6016', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210119046']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel J. DeAngelo', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, Massachusetts', 'The first 2 authors contributed equally to this article.'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210117453']}, {'raw_affiliation_string': 'The first 2 authors contributed equally to this article.', 'institution_ids': ['https://openalex.org/I4210119046']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102723376', 'display_name': 'Kristen E. Stevenson', 'orcid': 'https://orcid.org/0000-0002-0647-1431'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kristen E. Stevenson', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069208658', 'display_name': 'Jonathan E. Kolitz', 'orcid': 'https://orcid.org/0000-0003-2700-4784'}, 'institutions': [{'id': 'https://openalex.org/I1302444339', 'display_name': 'Northwell Health', 'ror': 'https://ror.org/02bxt4m23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan E. Kolitz', 'raw_affiliation_strings': ['Monter Cancer Center North Shore–Long Island Jewish Health System Lake Success New York'], 'affiliations': [{'raw_affiliation_string': 'Monter Cancer Center North Shore–Long Island Jewish Health System Lake Success New York', 'institution_ids': ['https://openalex.org/I1302444339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040287799', 'display_name': 'Julie Asch', 'orcid': 'https://orcid.org/0000-0001-9465-9778'}, 'institutions': [{'id': 'https://openalex.org/I2803026726', 'display_name': 'University of Utah Hospital', 'ror': 'https://ror.org/03b436430', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803026726']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julie D. Asch', 'raw_affiliation_strings': ['Latter Day Saints Hospital, Salt Lake City, Utah'], 'affiliations': [{'raw_affiliation_string': 'Latter Day Saints Hospital, Salt Lake City, Utah', 'institution_ids': ['https://openalex.org/I2803026726']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009091754', 'display_name': 'Philip C. Amrein', 'orcid': 'https://orcid.org/0000-0001-7770-2623'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Philip C. Amrein', 'raw_affiliation_strings': ['Massachusetts General Hospital Cancer Center, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089274301', 'display_name': 'Eyal C. Attar', 'orcid': 'https://orcid.org/0000-0002-1959-8079'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eyal C. Attar', 'raw_affiliation_strings': ['Massachusetts General Hospital Cancer Center, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090527595', 'display_name': 'David P. Steensma', 'orcid': 'https://orcid.org/0000-0001-5130-9284'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David P. Steensma', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047939331', 'display_name': 'Martha Wadleigh', 'orcid': 'https://orcid.org/0000-0002-8191-1708'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Martha Wadleigh', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063699585', 'display_name': 'Jared C. Foster', 'orcid': 'https://orcid.org/0000-0002-2931-4850'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julia Foster', 'raw_affiliation_strings': ['Massachusetts General Hospital Cancer Center, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063064811', 'display_name': 'Christine Connolly', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine Connolly', 'raw_affiliation_strings': ['Massachusetts General Hospital Cancer Center, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051795460', 'display_name': 'Ilene Galinsky', 'orcid': 'https://orcid.org/0000-0002-9158-5061'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ilene Galinsky', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073040359', 'display_name': 'Craig Devoe', 'orcid': 'https://orcid.org/0000-0002-2290-1884'}, 'institutions': [{'id': 'https://openalex.org/I1302444339', 'display_name': 'Northwell Health', 'ror': 'https://ror.org/02bxt4m23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Craig E. Devoe', 'raw_affiliation_strings': ['Monter Cancer Center North Shore–Long Island Jewish Health System Lake Success New York'], 'affiliations': [{'raw_affiliation_string': 'Monter Cancer Center North Shore–Long Island Jewish Health System Lake Success New York', 'institution_ids': ['https://openalex.org/I1302444339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071023119', 'display_name': 'Richard M. Stone', 'orcid': 'https://orcid.org/0000-0002-7526-2633'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard M. Stone', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003947352', 'display_name': 'Donna Neuberg', 'orcid': 'https://orcid.org/0000-0003-2566-3145'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Donna S. Neuberg', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045583767', 'display_name': 'Karen K. Ballen', 'orcid': 'https://orcid.org/0000-0003-1706-3975'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Karen K. Ballen', 'raw_affiliation_strings': ['Massachusetts General Hospital Cancer Center, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210087915']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5045583767'], 'corresponding_institution_ids': ['https://openalex.org/I4210087915'], 'apc_list': {'value': 4740, 'currency': 'USD', 'value_usd': 4740, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.163, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.999977, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '122', 'issue': '15', 'first_page': '2379', 'last_page': '2388'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10950', 'display_name': 'Epidemiology and Treatment of Childhood Leukemia', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10950', 'display_name': 'Epidemiology and Treatment of Childhood Leukemia', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11141', 'display_name': 'Pediatric Cancer and Quality of Life', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/treatment-outcomes', 'display_name': 'Treatment Outcomes', 'score': 0.537127}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.5109109}, {'id': 'https://openalex.org/keywords/asparaginase', 'display_name': 'Asparaginase', 'score': 0.5064074}, {'id': 'https://openalex.org/keywords/induction-chemotherapy', 'display_name': 'Induction chemotherapy', 'score': 0.48936337}, {'id': 'https://openalex.org/keywords/clofarabine', 'display_name': 'Clofarabine', 'score': 0.48731288}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9076495}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5956722}, {'id': 'https://openalex.org/C2779429289', 'wikidata': 'https://www.wikidata.org/wiki/Q408977', 'display_name': 'Vincristine', 'level': 4, 'score': 0.58014417}, {'id': 'https://openalex.org/C2911091166', 'wikidata': 'https://www.wikidata.org/wiki/Q106419912', 'display_name': 'Transplantation', 'level': 2, 'score': 0.56088597}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.5109109}, {'id': 'https://openalex.org/C2778904437', 'wikidata': 'https://www.wikidata.org/wiki/Q105296036', 'display_name': 'Asparaginase', 'level': 4, 'score': 0.5064074}, {'id': 'https://openalex.org/C2777408962', 'wikidata': 'https://www.wikidata.org/wiki/Q1128050', 'display_name': 'Hematopoietic stem cell transplantation', 'level': 3, 'score': 0.5059368}, {'id': 'https://openalex.org/C2776611710', 'wikidata': 'https://www.wikidata.org/wiki/Q16888295', 'display_name': 'Induction chemotherapy', 'level': 3, 'score': 0.48936337}, {'id': 'https://openalex.org/C2777198975', 'wikidata': 'https://www.wikidata.org/wiki/Q5134875', 'display_name': 'Clofarabine', 'level': 4, 'score': 0.48731288}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.4518095}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.4402011}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.42347923}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.37584496}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.33797106}, {'id': 'https://openalex.org/C2778041864', 'wikidata': 'https://www.wikidata.org/wiki/Q180983', 'display_name': 'Cytarabine', 'level': 3, 'score': 0.26678428}, {'id': 'https://openalex.org/C2776755627', 'wikidata': 'https://www.wikidata.org/wiki/Q408524', 'display_name': 'Cyclophosphamide', 'level': 3, 'score': 0.25593817}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.25429732}, {'id': 'https://openalex.org/C2909962599', 'wikidata': 'https://www.wikidata.org/wiki/Q180664', 'display_name': 'Lymphoblastic Leukemia', 'level': 3, 'score': 0.12092978}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018380', 'descriptor_name': 'Hematopoietic Stem Cell Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D054198', 'descriptor_name': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000367', 'descriptor_name': 'Age Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003131', 'descriptor_name': 'Combined Modality Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054198', 'descriptor_name': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D054198', 'descriptor_name': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D054198', 'descriptor_name': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012074', 'descriptor_name': 'Remission Induction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016019', 'descriptor_name': 'Survival Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014184', 'descriptor_name': 'Transplantation, Homologous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/cncr.30037', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.30037', 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27171984', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/cncr.30037', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.30037', 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.5}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1968020263', 'https://openalex.org/W1975280591', 'https://openalex.org/W1989658067', 'https://openalex.org/W2001772352', 'https://openalex.org/W2008009748', 'https://openalex.org/W2008532498', 'https://openalex.org/W2010729137', 'https://openalex.org/W2014461718', 'https://openalex.org/W2028757734', 'https://openalex.org/W2035343180', 'https://openalex.org/W2042138663', 'https://openalex.org/W2052739233', 'https://openalex.org/W2061266683', 'https://openalex.org/W2065851457', 'https://openalex.org/W2070394392', 'https://openalex.org/W2070520252', 'https://openalex.org/W2085533078', 'https://openalex.org/W2087090648', 'https://openalex.org/W2087529065', 'https://openalex.org/W2089224414', 'https://openalex.org/W2102776788', 'https://openalex.org/W2106275447', 'https://openalex.org/W2107925822', 'https://openalex.org/W2120508074', 'https://openalex.org/W2124174337', 'https://openalex.org/W2128491464', 'https://openalex.org/W2131046869', 'https://openalex.org/W2134118606', 'https://openalex.org/W2139674976', 'https://openalex.org/W2140291353', 'https://openalex.org/W2141962126', 'https://openalex.org/W2147083172', 'https://openalex.org/W2160881482', 'https://openalex.org/W2169732420', 'https://openalex.org/W2169961966', 'https://openalex.org/W2236930807', 'https://openalex.org/W2286519782', 'https://openalex.org/W2521731346', 'https://openalex.org/W2591881278', 'https://openalex.org/W2592474808', 'https://openalex.org/W2980143174', 'https://openalex.org/W4233655894', 'https://openalex.org/W57971082', 'https://openalex.org/W63408542'], 'related_works': ['https://openalex.org/W4240206086', 'https://openalex.org/W4230274130', 'https://openalex.org/W2594179475', 'https://openalex.org/W2101740056', 'https://openalex.org/W2091768197', 'https://openalex.org/W2066178485', 'https://openalex.org/W2024950851', 'https://openalex.org/W2005395645', 'https://openalex.org/W1973355371', 'https://openalex.org/W1536189216'], 'abstract_inverted_index': {'BACKGROUND': [0], 'Outcomes': [1], 'among': [2, 184], 'older': [3, 34], 'patients': [4, 33, 113, 138, 173], 'with': [5, 56, 207], 'acute': [6], 'lymphoblastic': [7], 'leukemia': [8], 'remain': [9], 'poor.': [10], 'This': [11], 'study': [12], 'sought': [13], 'to': [14, 82, 99, 194], 'determine': [15], 'the': [16, 72, 152, 165], 'efficacy': [17], 'of': [18, 109, 135, 212], 'an': [19], 'intensified,': [20], 'multi‐agent': [21], 'approach': [22], 'derived': [23], 'from': [24], 'a': [25, 118, 132], 'Dana‐Farber': [26], 'consortium': [27], 'trial': [28], 'in': [29, 78, 202, 205, 218], 'younger': [30], 'adults': [31], 'for': [32, 66, 131, 172], 'than': [35], '50': [36], 'years': [37], '(trial': [38], 'identifier': [39], 'NCT00973752).': [40], 'METHODS': [41], 'The': [42, 141, 155], 'primary': [43, 153], 'endpoint': [44], 'was': [45, 64, 147, 159, 170, 180], 'overall': [46], 'survival': [47, 168, 182], '(OS)': [48], 'at': [49, 144], '1': [50, 125, 145], 'year.': [51], 'Patients': [52, 77], 'received': [53], 'induction': [54, 89, 123], 'chemotherapy': [55, 199], 'vincristine,': [57], 'prednisone,': [58], 'doxorubicin,': [59], 'and': [60, 90, 106, 124, 149, 164, 192], 'pegylated': [61], 'asparaginase.': [62], 'Imatinib': [63], 'incorporated': [65, 75], 'Philadelphia': [67], 'chromosome–positive': [68], 'disease.': [69], 'After': [70], 'induction,': [71], 'first': [73], 'consolidation': [74, 91, 104, 129], 'clofarabine.': [76], 'remission': [79, 120], 'could': [80], 'proceed': [81], 'allogeneic': [83], 'hematopoietic': [84], 'cell': [85], 'transplantation': [86], '(HCT)': [87], 'after': [88, 122, 128], 'I.': [92], 'Those': [93], 'not': [94], 'receiving': [95], 'HCT': [96], 'went': [97], 'on': [98], 'receive': [100], 'central': [101], 'nervous': [102], 'system,': [103], 'II,': [105], 'continuation': [107], 'phases': [108], 'treatment.': [110], 'RESULTS': [111], 'Thirty': [112], 'were': [114], 'enrolled:': [115], '19': [116], 'achieved': [117, 126], 'complete': [119], '(CR)': [121], 'CR': [127, 133, 175], 'I': [130], 'rate': [134, 158, 169], '67%.': [136], 'Sixteen': [137], 'underwent': [139], 'HCT.': [140, 187], 'proportion': [142], 'surviving': [143], 'year': [146], '63%,': [148], 'this': [150, 219], 'met': [151], 'endpoint.': [154], '2‐year': [156, 166], 'OS': [157], '52%': [160, 171], '(n': [161, 176], '=': [162, 177], '30),': [163], 'disease‐free': [167], 'achieving': [174], '20).': [178], 'There': [179], 'no': [181], 'advantage': [183], 'those': [185], 'undergoing': [186], 'Therapy‐related': [188], 'hyperbilirubinemia': [189], 'prompted': [190], 'adjustments': [191], 'limitations': [193], 'asparaginase': [195], 'dosing.': [196], 'CONCLUSIONS': [197], 'Intensified': [198], 'can': [200], 'result': [201], 'improved': [203], 'outcomes': [204], 'comparison': [206], 'historical': [208], 'data.': [209], 'Additional': [210], 'studies': [211], 'similarly': [213], 'intensive': [214], 'regimens': [215], 'are': [216], 'warranted': [217], 'population.': [220], 'Cancer': [221, 227], '2016;122:2379–2388': [222], '.': [223, 229], '©': [224], '2016': [225], 'American': [226], 'Society': [228]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2385009615', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-08-15T14:18:47.716433', 'created_date': '2016-06-24'}