Title: The expressions of CD44v6 and PTEN in renal cell carcinoma and its clinical significance
Abstract: Objective:To investigate the expressions of CD44v6 and PTEN in renal cell carcinomal(RCC) and its clinical significance.Methods:The expressions of CD44v6 and PTEN were examined by immunohistochemistry S-P method in 20 cases of Para carcinoma,10 cases of normal renal tissues and 60 cases of RCC;And the pathobiologic behavior was analyzed.Results:The positive rates of CD44v6 and PTEN in RCC were 51.7% and 66.7%,respectively.The histological grading,clinical staging and metastases potential of RCC were correlated with high expression of CD44v6 and low expression of PTEN(P0.01).The expression of CD44v6 was negatively correlated with the expression of PTEN(P0.05-P0.01).Conclusions:The result suggests that high expression of CD44v6 and low expression of PTEN might be a useful indicator for evaluation of the differentiation of tumors and prediction of lymph nodes metastasis.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot