Title: The clinical observation on arsenic trioxide associated with ATRA in treating acute promyelocytic leukemia for six years
Abstract: Objective:To observe the effectiveness and the feature of arsenic trioxide (AS2O3) associated with ATRA in treating acute promyelocytic leukemia (APL). Method:Seventy-four cases of APL was provided randomly into two groups.Thirty-eight cases in treating group with AS2O3+ATRA,thiry-six cases in control group with AS2O3+ATRA+ chemotherapy (DA or MA). The observation was lasted for six years. Result:The first induce complete remission (CR) is 100%, the 3 years relapse rate is 2.6%, 6 years keep on alleviating rate (CCR) is 94.6% in the treating group. CR is 81.3%, 3 years relapse rate is 30.7%,CCR of 6 years is 61.5% in the control group. Bad reaction related to the treatment were lighter and less in the treacting group than in the control group.The three-year death rate respond to treating is 0 in treat group,while 16.7%(3/6) in control group.Conclusion:Arsenic trioxide associated with ATRA had strenger Synergy effect higher curative effect,lower relapse rate and lower side effect.and the resistance have not been seen.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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Cited By Count: 3
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