Title: EXPRESSION OF Ki67 PROTEIN ASSOCIATED WITH PROGNOSIS IN COLORECTAL CARCINOMA
Abstract: [Objective]To investigate the relationship between expression of Ki67 and prognosis of colorectal carcinoma(CRC).[Methods]The expression of Ki67 in 120 colorectal carcinoma specimens was detected by Streptavidin-Peroxidase immunohistochemical technique.[Results]The positive expression rate of Ki67 in CRC was 55.8%(67/120),The positive expression rate of Ki67 in CRC was significantly associated with tumor position?lymph nodes metastasis and Dukes' stage(P﹤0.05).The positive expression rate of Ki67 in CRC with lymph nodes metastasis was significantly higher than that without lymph nodes metastasis(P = 0.000);the positive expression rate of Ki67 was graduslly increasing when Dukes'stage deeping.Ki67 expression was correlated to survival time of CRC cases(P﹤0.001).[Conclusion]Ki67 expression in CRC is associated with tumor position,Dukes' stage,lymph nodes metastasis and survival time of CRC cases.Ki67 is probably a prognostic factor of CRC.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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