Title: Morphology of experimentally denervated and reinnervated guinea pig facial muscles
Abstract: Objective:To explore the morphological changes in orbicularis oculi muscle and orbicularis oris muscle after denervation.Methods:Guinea pig model of facial nerve paralysis was established by compressing the right facial nerve for 15 or 30 seconds or resecting the right facial nerve in 30 guinea pigs.The orbicularis oculi muscle and orbicularis oris muscle of both sides were sampled 1 week or 1 month after the operation.The morphology and ultrastructure of the muscles were observed under light microscope and transmission electron microscope after succinate dehydrogenase(SDH) staining,respectively.Results:In normal orbicularis oculi muscle,type I and type II muscle fibers accounted for 29.51% and 70.49%,respectively.In orbicularis oris muscle,the percentage of type II muscle fibers was 100%.After the injury of facial nerve,type I muscle fibers transformed to type II muscle fibers.With the recovery of facial nerve function to some extent,type I muscle fibers became more.The content of SDH in the muscles decreased after the injury of facial nerve and increased with the recovery of facial nerve function.Conclusion:The changes in muscle fiber types indicate the facial muscle function during denervation and reinnervation.The similar trend between the changes of facial muscle and facial nerve suggests that the pathological changes of facial muscle may be a standard to evaluate the status of facial nerve.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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