Title: Clinical effect of tolterodine on detrusor hyperreflexia of patients with spinal cord injury
Abstract: ObjectiveTo evaluate the effect and safety of tolterodine on detrusor hyperreflexia of patients with spinal cord injury.Methods20 cases of spinal cord injury patients with detrusor hyperreflexia were treated with tolterodine (2 mg, twice daily), and the data of urodynamics and voiding diary before and after treatment were evaluated.ResultsAfter 12 weeks of treatment, it showed a significant increase from baseline in mean voiding volume ( P0.01), functional bladder volume ( P0.05) and interval of voiding ( P0.01). The bladder volume at first contraction significantly increased from (62.62±36.37)ml to (126.75±34.64)ml ( P0.01), the maximal pressure of detrusor contraction significantly decreased from (74.81±28.60) cm H 2O to (61.90±16.22) cm H 2O ( P0.05), the maximal amplitude of wave significantly decreased from (47.24±30.42) cm H 2O to (39.36±25.28) cm H 2O.ConclusionTolterodine is effective and safety to detrusor hyperreflexia of patients with spinal cord injury, and has a better therapeutic compliance and less adverse reactions.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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