Title: Relationship between Serum Concentration of 638 Cases Anti-epileptic Drugs and Clinical Efficacy
Abstract: OBJECTIVE:To provide scientific reference for the rational use of anti-epileptic drugs(AEDs) in the clinic. METHODS:The serum concentrations monitoring resutts of valproic acid sodium,carbamazepine,phenytoin sodium and phenobarbital by fluorescence polarization immunoassay(FPIA) were analyzed retrospectively. RESULTS:Among 638 cases,there were 359 cases(56.27%)whose serum concentration were in therapeutic window,202 cases(31.66%)were in low range and 70 cases(10.97%)were in high range. Those of 7 cases(1.10%)could not be monitored. The percentage of serum concentrations of carbamazepine,phenobarbital,valproic acid sodium and phenytoin sodium in therapeutic window were 78.65%,60.00%,57.48% and 23.08%. The effective rates of carbamazepine,valproic acid sodium and phenytoin sodium in therapeutic window were 72.86%(χ 2=6.324,P=0.012),90.57%(χ2=122.782,P=0.000)and 94.44%(χ2=19.584,P=0.000),desperately,which were distinctly higher than other range of serum concentration(P0.05);there was no statistical significance in the effective rate of phenobarbital(χ2=3.403,P=0.065). Among 53 cases of drug combination,12 cases were in therapeutic window(22.64%). CONCLUSIONS: It is of great importance to monitor the serum concentration of anti-epilepsies drugs to provide the individual administration for patients and to ensure the safe,effective and rational use of drugs.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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