Title: Evaluation of Intravoxel Incoherent Motion Diffusion-Weighted Imaging in Differentiating Benign from Malignant Hepatic Neoplasm
Abstract: Objective To assess the value of intravoxel incoherent motion diffusion-weighted imaging in differentiating the benign hepatic neoplasm from malignant one. Methods A total of 63 patients with clinically-suspected space-occupying lesion in liver were enrolled in this study. Routine plain MR scanning,including T1WI,T2WI,DWI( b = 0,800 s /mm2),multi-b value DWI( b =0,20,50,100,200,400,600,800 and 1200 s/mm2) and dynamic contrast-enhanced scanning,were performed in all patients. The diagnosis in 52 patients( 70 lesions in total) was confirmed by pathology.The patients were divided into benign group( n = 21,32 lesions) and malignant group( n = 31,38 lesions). Fast-ADC,slow-ADC,fraction of fast ADC( FFADC) were measured by using MADC analysis software on a AW 4. 5 workstation,and their values in diagnosing and differentiating the benign and malignant hepatic tumors were determined,and the results were compared between the two groups. The prospective study protocol was approved by the Institutional Review Board and written-informed consent was obtained from all patients prior to the examination. Results Fast-ADC values of the benign group and malignant group were( 68. 64 ± 19. 00) × 10- 3mm2/s and( 55. 79 ± 14. 98) × 10- 3mm2/s respectively,while slow-ADC values of the benign group and malignant group were( 1. 88 ± 0. 43) × 10- 3mm2/s and( 0. 85 ± 0. 27) × 10- 3mm2/s respectively. FFADC values of the benign group and malignant group were( 29. 75 ± 16. 42) % and( 22. 95 ±8. 34) % respectively. Fast-ADC,slow-ADC and FFADC values of the benign group were higher than those of the malignant group. Significant differences in fast-ADC and slow-ADC values existed between the benign group and malignant group( P 0.05 in both),although the difference in FFADC values was not statistically significant between the two groups.Conclusion As important parameters of intravoxel incoherent motion diffusion-weighted imaging,both fast-ADC and slowADC play an important role in distinguishing benign hepatic neoplasm from malignant one.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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