Title: Species distribution and antifungal susceptibility of 143 Candida strains
Abstract: Objective To analyze the species distribution and antifungal susceptibility of 143 Candida strains isolated from clinical specimens.Methods A comprehensive study was carried out to analyze the species distribution of Candida spp.and their susceptibility to five commonly used antifungal agents.A total of 143 isolates were collected from Yan'an Hospital between 2005 and 2009.Antifungal susceptibility testing was conducted with ATB-Fungus-3 strip.Results Candida albicans accounted for 39.2%(56/143),and non-albicans Candida spp.60.8%(87/143),including Candida glabrata 24.5%(35/143),Candida tropicalis 7.7%(11/143) and Candida parapsilosis 5.6%(8/143).Of the 143 Candida isolates,the overall percentage of strains susceptible to flucytosine,amphotericin B,fluconazole,itraconazole,and voriconazole was 86.0%,100%,90.9%,69.9%,and 93.5%,respectively.About 91.1%,100%,96.4%,82.1%,and 96.3% of the 56 Candida albicans strains were susceptible to these five antifungal agents.Of the 87 non-albicans Candida spp.isolates,the susceptibility rates were 82.8%,100%,87.4%,62.1%,and 92.0%,respectively.Conclusions Candida albicans remains a common species in Candida infections.Non-albicans Candida spp.is also increasing.Candida albicans isolates are still highly susceptible to the common antifungal agents.Non-albicans Candida species are more resistant than Candida albicans.Clinical antifungal therapy should be based on the results of pathogen identification and antifungal susceptibility testing.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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