Title: Effect of tetrandrine on expression of apoptosis related-gene of vascular smooth muscle cells after balloon injury to vessel
Abstract: AIM:to investigate the mechanism of vascular smooth muscle cells (VSMC) apoptosis after balloon injury. To study the effect of Tet on the apoptosis and apoptosis related-gene expression of VSMC. METHODS:Apoptosis of VSMC,Bax protein and Bcl-2 protein was measured by TUNEL and immunohistochemical technique after balloon injury. RESULTS:After balloon injury,the vascular was proliferated. Apoptosis of VSMC appeared in intima and media of the vascular. Tet significantly increase the apoptosis of VSMC and decrease the thickness of intima an media after ballon injury (*P*0.05),and also can increase the area of vascular luminal. Tet significantly increase the expression of Bax protein and decrease the expression Bcl-2 protein(*P*0.05). CONCLUSION:Bax and bcl-2 contribute to the regulation of VSMC apoptosis after balloon injury. Tet can increase the apoptosis of VSMc by the regulation of Bax and Bcl-2 gene. The Tet could significantly inhibit VSMC proliferation and prevent the restenosis of blood vessel after balloon injury.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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