Title: Effect of Primary PCI and Post-thrombolysis Immediate Rescue PCI on Left Ventricular Function of Patients with Acute Myocardial Infarction
Abstract: Objective To evaluate effect and safty of primary percutaneous coronary intervention (PCI) versus reduced-dose rt-PA thrombolysis with immediate planned rescue PCI on the patients with acute myocardial infarction(AMI). Methods 63 patients with the first acute myocardial infarction within 6 hours from the onset of symptoms and without the contraindiction of thrombolytic therapy were randomly divided into primary PCI group (group A,32) and rt-PA thrombolytic therapy with immediate rescue PCI group (group B,31). Two-dimensional echocardiography was applied to record major cardiac events at the 3, 30 and 90 days after PCI. Results All patients were further divided into two groups according to TIMI-3 value. The differences of end-systolic volume index (ESVI),end-diastolic volume index (EDVI),left ventricular ejection fraction (LVEF) and wall motion scores index(WMSI) were not significant between group A and group B (P0.05) at 3, 30 and 90 days after operation. The differences of ESVI, EDVI, LVEF and WMSI were significant between 30d,90d and 3d in every group(P0.05). The differences of ESVI, EDVI, LVEF,WMSI were significant between TIMI-3 group and non-TIMI-3 group at 30d and 90d after operation. Conclusion There were identical effect and safty using primary PCI or reduced-dose rt-PA thrombolysis with immediate rescue PCI in the patients with AMI. They reduced cardiac events and improved left ventricular function and remodeling.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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