Title: Influence of Rat Bone Marrow Mesenchymal Stem Cells Cotransplanted with Bone Marrow to Severity of Graft vs Host Disease and Splenic Architecture
Abstract: 【Objective】 To investigate the effects of mesenchymal stem cells (MSC) on severity of graft vs host disease (GVHD) after allogeneic bone marrow transplantation (allo-BMT), especially on structural remodeling of spleen which was known as important peripheral immune organ and the GVHD target organ. 【Method】 BMT model from Fischer344 rats (RT-1Al) to Wistar rats (RT-1Au) was established. The rats' basic living conditions and the pathological changes of target organs such as the skin, the liver and the intestinal tract, as well as the reconstitution of splenic architecture especially were analyzed. 【Results】 It was demonstrated that the cotransplantation group had a higher survival rate at 30 days postransplant. The histology analysis showed that the skin, the liver, and intestinal tract in cotransplantation group were damaged relatively slightly. By histologic analysis, the spleens from cotransplantation group appeared nearly structural normal, with well-developed red and white pulp; while the spleens from BM transplantation group were atrophic, containing less T cells forming periarteriolar lymphoid sheaths (PALS),without distinct follicles. 【Conclusions】 Cotransplantation of MSC and the bone marrow could suppress GVHD, and remarkably promote reconstitution of splenic architecture.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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