Title: Effect of Continuous Pulmonary Artery Perfusion with Oxygenated Blood on Cytokine Levels after Cardiopulmonary Bypass
Abstract: Objective To study the effect of continuous pulmonary artery perfusion with oxygenated blood on cytokine levels during cardiopulmonary bypass(CPB). Methods 30 cases undergoing mitral valve replacement were randomly divided into control group (n=15) and lung perfusion group (n=15). All cases underwent routine mitral valve replacement except the cases in the lung perfusion group were perfused with oxygenated blood continuously via pulmonary artery during CPB. The patients'plasma concentrations of TNF-α and IL-8 were measured before surgery, at 0 h, 6 h after surgery by means of ABC-ELISA. Results Significant increasing(P0.05)of TNF-α and IL-8 levels were observed after surgery when compared with the same group at baseline(before surgery). Concentration of TNF-α and IL-8 at 0 h, 6 h post-operative in perfusion group were significantly reduced compared with control group (P0.05). Conclusion CPB could induce the increasing of TNF-α and IL-8 levels after surgery. Continuous pulmonary artery perfusion with oxygenated blood during CPB demonstrate the effect of reducing in postoperative TNF-α and IL-8 levels.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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