Title: Inhibition effects of combination of radiotherapy and endostar on rats with nasopharyngeal carcinoma xenografts and its mechanism
Abstract: OBJECTIVE: To observe the suppression of human nasopharyngeal carcinoma xenografts,growth,and the protein expression of vascular endothelial growth factor(VEGF) and proliferating cell nuclear antigen(PCNA).METHODS: Tumor xenografts were established in the male athymic nude mice(BALB/c-nu) by subcutaneous transplantation.The tumor-bearing mice were divided into four groups randomly: Control group was treated with saline;Endostar group was treated with endostar;radiotherapy group was treated with irradiation,and Combination group was treated with Endostar and irradiation.All mice were killed at the 11th after radiotherapy,the tumor growth curve and inhibition rates were calculated.Immunohistochemisty was adopted to check the protein expressions of VEGF and PCNA.RESULTS: Compared with Control group,the growth rates of the tumors in the other group were obviously slower,and the tumor volume were significantly different from Control group(P0.05).Compared with Control group,the expression of VEGF and PCNA protein in the other three groups were reduced,especially in Combination group(P0.05).CONCLUSIONS: Combination of radiotherapy and Endosta can significantly inhibit the nasopharyngeal carcinoma growth in rats.The possible mechanisms are to decrease the expression of VEGF and PCNA protein,then inhibiting angiogenesis and cell proliferation.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 1
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