Title: Relationship between CD4~+CD25~+ regulatory T cells and graftversus-host disease after allogeneic haematogenesis stem cell transplantation
Abstract: Objective To investigate the relationship between CD4+CD25+ regulatory T cells(CD4+CD25+T reg) and acute graft-versus-host disease(aGVHD) or chronic GVHD(cGVHD) after allogeneic haematogenesis stem cell transplantation(Allo-HSCT).Methods The percentage of CD4+CD25+T reg of peripherial blood in CD4+T cells in 50 patients with hematological malignancies after Allo-HSCT and 24 healthy people were detected by flow cytometry.Results All the patients achieved engraftment.The percentage of CD4+CD25high,CD4+CD25+CD127low T in the groups of normal control and those without GVHD were(2.185±0.582)% and(6.365±2.155)%;(2.320±2.813)% and(7.515±5.457) respectively(P0.05);The percentage of CD4+CD25high,CD4+CD25+CD127low T in the groups of aGVHD were(1.270±1.385)% and(4.575±3.900)%,declined significantly compared with those of normal control and without GVHD(all P0.01).The percentage of CD4+CD25+ T reg in the peripheral blood of patients with Ⅱ-Ⅳ aGVHD declined significantly compared with Ⅰ aGVHD(P0.01) and there was significant difference between extensive cGVHD and limited cGVHD(P0.05).Conclusion CD4+CD25+ T reg cell level is relative to aGVHD or cGVHD.It is very significant in clinic to detect CD4+CD25+T reg after Allo-HSCT.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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