Title: Effect of Cystatin C on evaluation of glomerular filtration function in chronic kidney disease patients
Abstract: Objective: To compare the coincidence of Cystatin C, serum creatinine,creatinine clearance(Ccr) in each eGFR stage of chronic kidney disease(CKD) patients.Methods: Cystatin C was measured by turbidimetric method,Creatinine in serum and urine were determined by enzyme method,while eGFR was calculated using the abbreviated MDRD equation which was mainly based on the serum creatinine concentration.According to the American NKF-K/DOQI guideline,all cases were grouped by eGFR into 5 stages. Results: In these 168 cases,as eGFR decreased gradually,the average levels of Cystatin C and creatinine increased,while Ccr decreased.The level of each items showed a statistic difference among each stage(P0.05),in eGFR≤29 ml/min groups,the abnormal rate of Cystatin C,Scr,Ccr were all 100%,and the average levels of Cystatin C and Scr were 3~6 times and 4~5 times to the upper reference limit,while Ccr was 4~7 times to the lower reference limit;in eGFR 30~59 ml/min groups,the average levels of Cystatin C,Scr and Ccr were 2.06 mg/L,131.2 μmol/L and 45.6 ml/min,and the abnormal rate were 97%,80% and 89% respectively,no statistic difference was observed among the three rates(P0.05);in eGFR 60~89 ml/min groups,the level of Cystatin C and Ccr showed a marginal increase and decrease,with an abnormal rates of 87% and 69%,the abnormal rate of Scr was 6.5%,there was a statistic difference among the three abnormal rates(P0.05);when eGFR≥90 ml/min,the abnormal rates of Cystatin C and Ccr reached to 60% and 42%,while the abnormal rate of Scr was 0,respectively. Conclusion: when eGFR was less than 60 ml/min,it showed a good coincidence with Cystatin C,Scr and Ccr,at this time a conclusion could be drown that glomeruler filtration function had decreased moderately;when it was 60 ml/min≤eGFR≤89 ml/min,Cystatin C and Ccr could at least select out 2/3 patients with abnormal GFR,but Scr could not reflect the damage on GFR,and Cystatin C was more sensitive than Ccr;and when eGFR≥90 ml/min,MDRD equation overestimated the real GFR,so it was not fit for patients with a normal Scr level,especially to the elder CKD patients,for these patients,it was requested to check Cystatin C and Ccr to find out GFR damage timely.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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