Title: Implication of the Expression of BCRP in Breast Cancer Stem Cells
Abstract: Objective To examine the expression of BCRP in breast cancer stem cells and its implication.Methods Flow cytometry was employed to separate breast cancer stem cells from human breast cancer tissue.Then the expression of BCRP was detected by real time PCR in different subsets of cells.Results Compared with the non-stem cells of breast cancer,the expression of BCRP in breast cancer stem cells was significantly higher(P0.01),and the proportion of stem cells was increased after chemotherapy(P0.01).Conclusion The breast cancer stem cells can increase their drug resistance by enhancing the expression of BCRP,which is the key factor that leads to the failure of cancer therapy.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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