Title: Effects of an antioxidant (An7845) on the proliferation and apoptosis of K562 leukemia cells
Abstract:OBJECTIVE To determine the effects of an antioxidant (An7845) on the proliferation inhibition and apoptosis induction of a human leukemia cell line (K562). METHODS We evaluated the effects of An7845 o...OBJECTIVE To determine the effects of an antioxidant (An7845) on the proliferation inhibition and apoptosis induction of a human leukemia cell line (K562). METHODS We evaluated the effects of An7845 on K562 cell proliferation by cellular enumeration in liquid culture assay, MTT assay and colony formation assay. We also verified the effects of An7845 on K562 cell apoptosis by cellular morphology and the DNA fragments appeared in agarose gel electrophoresis. RESULTS The proliferation of K562 leukemia cells was inhibited by An7845 (5 x 10(-8) - 5 x 10(5) mol/L) in a dose-dependent manner. K562 cells were induced toward apoptosis by An7845 (5 x 10(-7) mol/L). CONCLUSION An7845 can effectively inhibit the proliferation and induce the apoptosis of K562 leukemia cells.Read More
Publication Year: 2004
Publication Date: 2004-06-01
Language: en
Type: article
Indexed In: ['pubmed']
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