Title: The Analgesic Effect and Safety of Continuous Intravenous Infusion of Small Dose of Ketamine Combined with Sufentanyl for Postoperative Patients of Lower Limb Fracture
Abstract: Objective To observe the analgesic effect and safety of continuous intravenous infusion of small dose of ketamine combined with sufentanyl for postoperative patients of lower limb fracture.Methods 60 postoperative patients were randomly divided into two groups with 30 cases each.Intravenous postoperative analgesia was administered to experiment group(sufentanyl 0.35μg/kg.h + ketamine 35μg /kg.h),control group(sufentanyl 0.5 μg/kg.h).The parameters,such as pain score of VAS,incidence of side effect including itch,nausea,vomiting and central excitatory phenomena,and SpO2 were recorded respectively at 12,24,and 48 hours after operation.Results The pain score of E Group at each time point was significantly lower than that of C Group.There were significant differences in the incidence of nausea,vomiting.No significant differences in itching and urine retention among these groups.No case with central excitatory phenomena was found in each group.At each time point,no significant difference in SpO2 was found among the two groups,and all the SpO2 values were not less than 96%.Conclusion Ketamine at 35 g/kg.h can enhance the efficacy of sufentanyl(0.35g/kg.h) without increasing side effect events.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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