Title: Clinical study of therapeutic effect of controlled external ventricular drainage on post-operative brain swelling in severe traumatic brain injury
Abstract: Objective To investigate the therapeutic effect of controlled external ventricular drainage on post-operative brain swelling in severe traumatic brain injury.Methods A total of 82 patients(treatment group)with brain swelling in severe traumatic brain injury after operation,who were admitted to the hospital between Jan.2009 and Jun.2012,were treated by dehydration therapy,anti-infective therapy,neurotrophic treatment,nutrition support,and so on;in addition,controlled external ventricular drainage was put into effect immediately after the diagnosis of brain swelling,and the indwelling time of drainage tube was 4-9 days,whose average was 6.8 days.Their outcomes were compared retrospectively with those of 72 patients(control group)with brain swelling in severe traumatic brain injury after operation,who were admitted to the hospital between Jan.2005 and Dec.2008.In control group,the patients received the same treatment measures as those in treatment group,except the controlled external ventricular drainage.The intracranial pressure(ICP)and cranial perfusion pressure(CPP)of every patient were measured,and the state of intracranial infection and traumatic hydrocephalus was recorded.According to Glasgow Outcome Scale(GOS),the therapeutic effect of each patient was evaluated 3 months later;furthermore,the awakening(recovery of consciousness)time of each patient was recorded.Results In comparison with control group,the amount of high-value ICP in early stage after injury in treatment group decreased significantly(P0.01),yet the amount of low-value CPP increased significantly(P0.01).The incidence rate of intracranial infection in treatment group was not increased,and the incidence rate of traumatic hydrocephalus in treatment group was significantly lower than that of control group(P0.05).The total effective rate of treatment group was significantly higher than that of control group(P0.05),yet the ineffective rate of treatment group was significantly lower than that of control group(P0.05).Moreover,the average awakening time of treated group was shortener than that of control group significantly(P0.01).Conclusion The application of controlled external ventricular drainage to patients with brain swelling in severe traumatic brain injury after operation can lower the intracranial pressure,raise the cranial perfusion pressure,improve the curative effect significantly,shorten the duration of coma,and reduce the incidence of traumatic hydrocephalus,which deserves further clinical applications.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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