Title: Correlation of IL-6 level in cervical mucus with follicle development and ovulation in different protocols of ovulation stimulation
Abstract: AIM:To investigate the level of IL-6 in cervical mucus when applying variable protocols of ovulation stimulation,and its possible correlation with either follicle development or ovulation.METHODS:Thirty-six patients with infertility were observed in this study,and 15 women with normal menstruation and conception were taken as controls.The patients were divided into 3 subgroups according to the ovulation stimulating protocol they received:clomiphene,menotrophin(HMG)and controlled ovarian hyperstimulation(COH)subgroups.We collected cervical mucus and serum,respectively during early follicular phase,peri-ovulation phase,and mature luteal phase,and tested IL-6,FSH,LH,E2,and P levels of both mucus and serum using double radioimmunoassay.Simultaneously,the condition of follicle development,thickness of endometrium and ovulation were monitored by transvaginal ultrasonography.RESULTS:① IL-6 of cervical mucus appeared periodical changes along the menstrual and ovulating cycle:ascending in follicular phase,reaching the platform in ovulation phase,declining as stepping into luteal phase,with statistical difference among different phases(P0.05).② IL-6 in cervical mucus showd a positive correlation with the size of follicle(r=0.792,P0.05),but no obvious relationship with the thickness of endometrium and the score of mucus.③ Compared with unovulation group,IL-6 level was significantly higher in ovulation group(P0.05).CONCLUSION:① Periodical variation and ovulation phase peak level of IL-6 in cervical mucus might make it a potential marker applied for forecasting ovulation.② IL-6 level in cervical mucus is distinctively higher in HMG group and IVF-ET COH group than in control cases,which is probably due to up-regulation effect of Gn for IL-6.③ IL-6 might play a key role in the process of follicle development and ovulation.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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