Title: The Damage Induced by Chronic Stress on the Spatial Learning and Memory Abilities of Rats and Pertinent Mechanism
Abstract: Objective To study the damage induced by chronic stress on the spatial learning and memory abilities of rats and pertinent mechanism. Methods Chronic stress model was established by electric-foot accompanied with noise. The Morris water maze was used to observe the spatial learning and memory abilities of the animals. The intrasynaptosomal free Ca 2+ concentration of hippocampus was measured by Fara-2 fluorescent. Results Chronic stress resulted in decrease of the spatial learning and memory abilities of rats and remarkable increase of the intrasynaptosomal free Ca 2+ concentration of hippocampus. Conclusion The spatial learning and memory dysfunction induced by chronic stress may be associated with the high intrasynaptosomal Ca 2+ level of hippocampus.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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