Title: Ultrastructural Alterations of Hippocampal Neuron Synapses in Rats with Increasing Age
Abstract: Objective To observe and compare the ultrastructural changes of synapses in hippocampal neurons in rats with increasing age.Methods The ultrastructure of synapses and lipofuscin granules in hippocampal neurons of Sprague Dawley rats at the age of 1 day,1,3,6,18 and 24 months were observed by transmission electron microscopy.Results Synaptic structures in hippocampal neurons were almost absent in the 1-day neonatal rats,gradually increased from 1 month to 6 month-old,then decreased,and almost disappeared at the age of 24 months.The lipofuscin granules emerged in hippocampal neurons of 1 month-old rats,and increased with ageing.The presence of lipofuscin granules was most numerous at 24 months of age.Conclusion Synaptic structures in the rat hippocampus show prominent changes with increasing age,revealed by electron microscopy.Most well developed synaptic structures are present in young rats,and impaired in aged rats,meanwhile there are lots of deposits of lipofuscin granules in the brain neurons of aged rats.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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