Title: Clinical study of stereotactic radiotherapy boost on improvement of local control and survival of nasopharyngeal carcinoma
Abstract: Objective To study the effects of stereotactic radiotherapy boost on the improvement of local control and survival of nasopharyngeal carcinoma. Methods Thirty-two consecutive patients were treated with stereotactic radiotherapy after radiotherapy for nasopharyngeal carcinoma from May 1998 to December 2002. All patients had biopsy confirmation of disease prior to radiation therapy: Stage Ⅰ disease (1 patient), Stage Ⅱ disease (16 patients), Stage Ⅲdisease (8 patients), and Stage Ⅳ disease (6 patients). Stereotactic radiotherapy was delivered with a frame-based LINAC as a boost (range: 8 to 20 Gy, median: 12 Gy) following fractionated radiation therapy (range: 64 to 72 Gy, median: 66 Gy). Results Four patients developed local recurrences, 3 cervical node recurrences, and 6 distant metastases at a mean follow-up of 33 months (range: 6 to 51 months). The local control rate in 1, 2, and 3 years after treatment for primary site were 96.3%, 89.0%, and 85.0% respectively. The disease free survival rate in 1, 2, and 3 years were 92.6%, 77.3% and 66.0%, respectively. There were no complications of treatment caused by stereotactic radiotherapy except for 1 patient who died from nasopharyngeal hemorrhage. Conclusion Stereotactic radiotherapy boost following fractionated EBRT can result in excellent local control and longer disease-free survival.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot