Title: Detection of survivin,PTEN,and p53 gene in colon carcinoma tissue
Abstract: Aim:To detect expressions of antiapoptosis gene survivin,anti-oncogene PTEN and p53,and their relationship with tumor progress and clinical pathological characteristics in colon carcinoma tissue.Methods:The expressions of survivin,PTEN and p53 were examined by immunohistochemistry S-P in 59 cases of colon carcinoma,20 cases of enteric adenoma,and 19 cases of normal colon tissue.Results:The positive rates of survivin,PTEN,and mutant p53 were 64.4%,54.2% and 66.1% in colon carcinoma tissue.The survivin gene and mutant p53 gene were not expressed in normal colon tissue or enteric adenoma tissue.PTEN gene was expressed in almost all the normal colon tissue and enteric adenoma tissue.The positive rates of survivin gene and mutant p53 gene in colon carcinoma tissue were higher than those in normal colon tissue and enteric adenoma tissue.The positive rate of mutant p53 increased while that of PTEN decreased with the increase of Duck's stage,changes of histological type,and lymph node metastasis(P0.05).In colon carcinoma tissue,the expression of survivin was positively correlated with that of mutant p53(r=0.813 5,P0.05),and negatively correlated with PTEN(r=-0.773 5,P0.05).The expression of PTEN was negatively correlated with that of mutant p53(r=-0.935 0,P0.05).Conclusion:Abnormal expressions of survivin,PTEN,and mutant p53 gene are related to tumor malignant progress and pathological characteristics of colon carcinoma.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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