Title: Changes of Pulmonary Diffusing Capacity and Pulmonary Capillary Blood Volume in Stable COPD Patients with Mixed Ventilation Dysfunction
Abstract:Objective To investigate the changes of pulmonary diffusing capacity and pulmonary capillary blood volume in stable COPD patients with mixed ventilation dysfunction,and explore the possible pathophysi...Objective To investigate the changes of pulmonary diffusing capacity and pulmonary capillary blood volume in stable COPD patients with mixed ventilation dysfunction,and explore the possible pathophysiological factors.Methods 159 stable COPD patients with mixed ventilation dysfunction were recruited in the study and 36 normal subjects were recruited as control.The Belgium medisoft box5500 was used to determine the pulmonary ventilation function,lung capacity,and pulmonary diffusing capacity.The measured parameters included forced vital capacity(FVC),forced expiratory volume in one second(FEV1),maximal voluntary ventilation(MVV),vital capacity(VC),total lung capacity(TLC),residual volume(RV),minute volume of alveolar ventilation(VA),lung diffusing capacity for carbon monoxide(DLCO),pulmonary membrane diffusing capacity for carbon monoxide(DMCO),and pulmonary capillary blood volume(Vc).The above parameters were compared between the COPD patients and the normal subjects.The relationship was analyzed between DLCO%pred,DMCO%pred,Vc%pred and all the ventilation parameters.Results In stable COPD patients with mixed ventilation dysfunction,all parameters of pulmonary ventilation function,lung capacity,and pulmonary diffusing capacity were significantly different from the nor mal subjects(P0.05 or P0.01).FVC,VC,VA,and DMCO of the C OPD patients wer e about 66% of the calculated value or more.The average TLC%pred was a little hi gher than the normal.FEV1,MVV,DLCO and Vc were abnormally lower which were bet ween 36%~44%.The average RV%pred was 188% of the predicted value.Obvious correla tion could be detected between DLCO%pred,DMCO%pred,Vc%pred and FEV1%pred,FEV1 /FVC,TLC%pred,RV%pred,RV/TLC and VA%pred etc.Conclusions In COPD patients wi th mixed ventilation dysfunction,the pulmonary blood capillary is damaged serio usly which lead to a significant decrease of the capacity of pulmonary blood cap illary,as well as seriously air distribution disturbance and ventilation/bloods tream mismatch.The Vc decline may develope before the impairment of pulmonary di ffusing capacity which may contribute to the damaged of DLCO and DMCO.Read More
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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