Title: Serum level of MMP-3 and the expressions of VEGF-C and MMP-3 in gastric cancer
Abstract: Objective: To investigate the level of MMP-3 in the serum of gastric cancer pa-tients and to examine the expression of VEGF-C in gastric cancer, to evaluate the effects of the two factors on the development process of cancer. Methods: The enzyme linked immunosorben assay (ELISA) method was used to detect the serum levels of MMP-3 in 50 patients with gastric cancer. The immunohistochemical method was utilized to analyze the expressions of VEGF-C and MMP-3 in 50 resected specimens. Results: The preoperative serum level of MMP- 3 (30.96±9.75 ng/mL) was significantly higher than that of postoperative group (16.29 ±5.92 ng/mL) and control group (14.43±4.82 ng/mL) (P0.05). Preoperative serum MMP- 3 level was closely related with the extent of cancer invasion, TNM stage and lymph node metastasis (P0.05). The positive expression of MMP-3 (68% ) was closely related with TNM stage of gastric cancer and lymph node metastasis (P0.05). Preoperative serum level of MMP-3 showed consistency with the expression of MMP-3 in gastric cancer. The positive expression of VEGF-C (50% ) was closely related with the degree of gastric cancer invasion and lymph node metastasis (P0.05). The expression of VEGF-C was positively correlated with that of MMP-3 (P0.05). Conclusion: VEGF-C and MMP-3 play an impor-tant role in tumor invasion and metastasis. The detection of preoperative and postoperative serum levels of MMP- 3 has important clinical significance in predicting invasion and metastasis of gastric cancer, and also in determining prognosis of gastric cancer.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot