Title: Expression and clinical significance of 15-LOX-1 in gastric carcinoma
Abstract: Objective To detect the expression of 15-lipoxygenase-1(15-LOX-1) mRNA and protein in gastric carcinoma and adjacent normal tissue,and to investigate the relationship between the expression of 15-LOX-1 and clinical pathological characteristics. ?Methods The 15-LOX-1 mRNA and protein level were detected in pairs of gastric carcinoma and adjacent normal tissue by reverse transcription polymerase chain reaction(RT-PCR),immunohistochemistry and western blot methods.?Results The expression of 15-LOX-1 mRNA and protein in gastric carcinoma was lower than those in the adjacent normal tissue significantly(P0.05). There was significantly negative correlation between 15-LOX-1 protein expression and clinical pathological characters such as tumor size,lymph node metastasis and TNM stage(P0.05). ?Conclusion The 15-LOX-1 protein may restrain the genesis and progress of gastric carcinoma.The assay of 15-LOX-1 expression in gastric carcinoma may be helpful to evaluate the prognosis of the patients with gastric carcinoma.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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