Title: Effects of dexmedetomidine on patients with anesthesia hypertension about stress reaction between the extubation period
Abstract: AIM:To observe the effect of dexmedetomidine on patients with anesthesia hypertension about stress reaction between the extubation period.METHODS: 60 patients with previous history of hypertension,stable blood pressure control,gastric cancer surgery were enrolled in the research.The patients were randomly divided into dexmedetomidine 0.5 μg/kg group(group D1),dexmedetomidine 1 μg/kg group(group D2) and saline control group(group C),n=20.All the patients were used inhalation anesthesia.Dexmedetomidine 0.5 μg/kg,1 μg/kg,and normal saline 20 mL were given with micro-pumps intravenous inject at 60 min before the end of surgery,the infusion time was 30 min.Before anesthesia,before extubation,after extubation 1,3,5,10 min,the hemodynamic parameters were recorded,the levels of plasma epinephrine(E),norepinephrine(NE),cortisol(COR),glucose(GLU),blood lactate(LAC)were determined,and the levels of lanesthesia time,wake time,extubation time were recorded.RESULTS:The levels of MAP,HR,plasma E,NE,COR,GLU,LAC in three groups were significantly higher than those of before anesthesia(P0.01 or P0.05).The levels of MAP,HR,plasma E,NE,COR,GLU,LAC in group C were higher than those of group D1,group D2(P0.01 or P0.05).The levels of wake-up time,extubation time in group D2 were higher than those of group C,group D1(P0.05).CONCLUSION: Dexmedetomidine can inhibit the stress response which is caused by tracheal extubation,and the appropriate dose is 0.5 μg/kg.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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