Title: Tailored approach to sonographically guided percutaneous microwave coagulation therapy for hepatocellular carcinoma
Abstract: Objective:To evaluate the effectiveness of tailored approach to percutaneous microwave coagulation therapy for hepatocellular carcinoma(HCC).Methods: Ultrasound-guided percutaneous microwave coagulation therapy was performed in 902 tumors of 750 patients,including 176 near the bowel,383 near the diaphragm,163 near the gallbladder,and 180 near the liver surface.The tumor sizes ranged 1.5-6.8 cm [mean(4.0±2.2)cm].A tailored treatment strategy was established for tumors in different locations Contrast-enhanced CT was performed one month later to evaluate the early necrosis rate of the treated tumors.Results: Early tumor necrosis rate was 90.3% of the peripherally located HCC,including 90.3% of the tumors near the bowel,89.5% near the diaphragm,91.7% near the gallbladder,and 93.1% near the liver surface.Local tumor recurrence rates were 9.1%,9.9%,8.1%,and 7.0% for tumors near the bowel,diaphragm,gallbladder,and liver surface,respectively.The 1-,2-,and 3-year survival rates of were 81.9%,60.8%,and 50.6%,respectively.Major complications occurred in 3.6%,including abdominal bleeding(n=3),nearby structure injury(n=6),needle tract seeding(n=9),hepatic subcapsular(n=15) and liver abscesss(n=5).Conclusion: The tailored approach to PMCT provides a promising treatment option for refractory peripherally located HCC with satisfactory tumor necrosis rate and low complication rate.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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