Title: Neutralizing Activity and Preventive and Curative Effects of Human McAb to Tetanus Toxin
Abstract:Objective To explore the neutralizing activity as well as preventive and curative effects of human McAb to tetanus toxin. Methods Two cell strains secreting McAb to tetanus toxin were cultured and the...Objective To explore the neutralizing activity as well as preventive and curative effects of human McAb to tetanus toxin. Methods Two cell strains secreting McAb to tetanus toxin were cultured and the secreted McAbs were purified and subject to control tests. Results The tests in mice showed in vitro neutralizing activity of the McAb.The McAb at a high dosage neutralized tetanus toxin completely and prolonged the survival period of mice significandy. Different McAbs showed different neatralizing activities. However, all of them showed preventive and curative effects on the mice challenged with tetanus toxin at a lethal dosage. Conclusion The human McAb can be used for the prevention and treatment of tetanus infection.Read More
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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