Title: Simultaneous determination of four acidic pharmaceuticals and personal care products by solid phase extraction-high performance liquid chromatography
Abstract: A solid phase extraction followed by high performance liquid chromatography method had been established for the determination of four acidic pharmaceuticals and personal care products.Water samples were filtered through 0.22 μm glass-fiber filters twice,and concentrated through C18 solid phase extraction column.The solutions were analyzed by HPLC directly.The linearity ranges were 5-200 μg/L for Salicylic acid,2-200 μg/L for Ketoprofen,0.5-50 μg/L for Naproxen and 5-200 μg/L for Diclofenac sodium,respectively.The limits of detection(LODs) were 0.15 μg/L for Salicylic acid,0.18 μg/L for Ketoprofen,0.03 μg/L for Naproxen and 0.6 μg/L for Diclofenac sodium,respectively.The recoveries of the pharmceuticals ranged from 80.2% to 104.3%.The method is simple,fast,low-cost,high recovery rate,enrichment factor and is suitable to the detection of PPCPs residues in enviromental water samples.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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